This paper notes: “One fact remains abundantly clear: for every known human carcinogen that has been tested adequately in laboratory animals, the findings of carcinogenicity are concordant.” According to Watterson (2014): “In this major paper, Huff looks at the predictive value of animal studies and examines long-term carcinogenesis bioassays used to identify human carcinogens and their drawbacks. The importance of mixtures and a host of factors, including occupational exposures to cancer etiology, are discussed: though difficult such factors could be explored experimentally. The higher public health risks from false negatives are noted.”

James Huff.  Long-term chemical carcinogenesis bioassays predict human cancer hazards: Issues, controversies, and uncertainties, Annals of the New York Academy of Sciences, volume 895, pages 56-79, 1999.